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Description
The neuroprotective activities of GLP-1RAs against PD can be, at least partially, mediated by PI3K/AKT pathway that modulates several downstream molecules, such as cAMP response element-binding protein (CREB), glycogen synthase 3 (GSK-3), Forkhead box O1/O3 (FoxO1/O3), and mammalian target of rapamycin (mTOR) (Athauda and Foltynie, 2016) (Figure 1B)
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Additionally, pFUS improved glucose homeostasis in mice fed a Western diet, highlighting its potential to counteract diet-induced metabolic disturbances (Cotero et al

Neuron 66 , 681694 (2010)
